특허

번호 발명의 명칭 출원/등록 번호 출원/등록 국가
1. 삼차원 배양피부모델을 이용한 상처치유능 분석방법 10-2285683-00-00 KR
2. 진피층 및 표피층을 포함하는 삼차원 배양 피부모델을 제조하는 방법 및 이를 통해 제조된 삼차원 배양 피부모델 10-1613618 KR
3. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom PCT/KR2015/007118 PCT
4. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom 15/324,277 US
5. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom 2017-501265 JP
6. Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin made therefrom 15819565.1 EU




논문 · Neoderm®-ED

번호 논문자료 저널명 파일
1. Sustained drug release behavior of captopril-incorporated chitosan/carboxymethyl cellulose biomaterials for antihypertensive therapy International Journal of Biological Macromolecules. 2024
2. Exosomes derived from human dermal fibroblasts (HDFn-Ex) alleviate DNCB-induced atopic dermatitis (AD) via PPARα Experimental Dermatology. 2023
3. Photothermally controlled drug release of naproxen-incorporated mungbean starch/PVA biomaterials adding melanin nanoparticles Process Biochemistry. 2023
4. Bioconversion of BIOGF1K, a compound-K-rich fraction from ginseng root and its effect on epidermal barrier function Heliyon. 2023
5. Topical Application of Peptide Nucleic Acid Antisense Oligonucleotide for MMP-1 and Its Potential Anti-Aging Properties Journal of Clinical Medicine. 2023
6. Safety Assessment of Starch Nanoparticles as an Emulsifier in Human Skin Cells, 3D Cultured Artificial Skin, and Human Skin Molecules. 2023
7. otential role of the cell-penetrating peptide-conjugated soluble N-ethylmaleimide-sensitive factor attachment protein receptor motif of vesicle-associated membrane protein 2-patterned peptide in novel cosmeceutical skin product development Journal of Cosmetic Dermatology. 2023
8. Exosomes derived from human dermal fibroblasts protect against UVB‑induced skin photoaging International Journal of Molecular medicine . 2023
9. Rosa gallica and its active compound, cyanidin-3,5-O-diglucoside, improve skin hydration via the GLK signaling pathway Biofactors. 2022
10. Synthesis and drug release properties of melanin added functional allopurinol incorporated starch-based biomaterials International Journal of Biological Macromolecules. 2022
11. Noninvasive Transdermal Delivery of Biomolecules Using Arc-Poration Social Science Research Network. 2022
12. Transdermal Delivery and Biological Activity of Arginine Oligomer Conjugation of Palmitoyl Tripeptide-1 International Journal of Innovative Research and Scientific Studies. 2022
13. Enhancement of Efficacy of Retinoids through Enhancing Retinoid-Induced RAR Activity and Inhibiting Hydroxylation of Retinoic Acid, and Its Clinical Efficacy on Photo-Aging Pharmaceutics. 2022
14. Inhibition of Chitinase-3-like-1 by K284-6111 Reduces Atopic Skin Inflammation via Repressing Lactoferrin Immune Netw. 2021
15. Radioprotective effects of Cryptosporidium parvum lysates on normal cells Int J Biol Macromol. 2021
16. Synthesis of Retinol-Loaded Lipid Nanocarrier via Vacuum Emulsification to Improve Topical Skin Delivery Polymers. 2021
17. Enhancing skin permeation of nanoemulsions through associative polymeric micelles-mediated drop-to-skin dipolar interactions J Mol Liq. 2021
18. Enhancement of Skin Permeation of Anti-wrinkle Peptide GHKs Using Cell Penetrating Peptides 한국공업화학회. 2021
19. Preparation and Release Properties of Acetaminophen Imprinted Functional Starch based Biomaterials for Transdermal Drug Delivery 한국공업화학회. 2021
20. Preparation and evaluation of functional allopurinol imprinted starch based biomaterials for transdermal drug delivery Int J Biol Macromol. 2021
21. Cicadidae Periostracum Attenuates Atopic Dermatitis Symptoms and Pathology via the Regulation of NLRP3 Inflammasome Activation Oxid Med Cell Longev. 2021
22. Enhanced Nrf2 up‐regulation by extracellular basic pH in a human skin equivalent system J Cell Mol Med. 2021
23. Inhibition of Solar UV-Induced Matrix Metalloproteinase (MMP)-1 Expression by Non-Enzymatic Softening Cherry Blossom (Prunus yedoensis) Extractl Plants. 2021
24. Ethanol Extract of Yak-Kong Fermented by Lactic Acid Bacteria from a Korean Infant Markedly Reduces Matrix Metallopreteinase-1 Expression Induced by Solar Ultraviolet Irradiation in Human Keratinocytes and a 3D Skin Model Antioxidant. 2021
25. Oral Administration of Rosa gallica Prevents UVB− Induced Skin Aging through Targeting the c− Raf Signaling Axis Antioxidant. 2021
26. Photoprotective Activity of Topsentin, A Bis(Indole) Alkaloid from the Marine Sponge Spongosorites genitrix, by Regulation of COX-2 and Mir-4485 Expression in UVB-Irradiated Human Keratinocyte Cells Marine drugs. 2020
27. rhEGF Treatment Improves EGFR Inhibitor-Induced Skin Barrier and Immune Defects Cancers. 2020
28. Identification of new arylsulfide derivatives as anti-melanogenic agents in a zebrafish model Bioorganic & Medical Chemistry Letters. 2020
29. Diosmin restores the skin barrier by targeting the aryl hydrocarbon receptor in atopic dermatitis Phytomedicine. 2020
30. IL-32γ suppressed atopic dermatitis through inhibition of miR-205 expression via inactivation of nuclear factor-kappa B J allergy clin immunol. 2020
31. Antiphotoaging Potential of Extracts of Yin-Tonic Herbal Medicine in Skin Cell and Human Skin Equivalent Evid Based Complement Alternat Med. 2020
32. Astragali Radix and its compound formononetin ameliorate diesel particulate matter-induced skin barrier disruption by regulation of keratinocyte proliferation and apoptosis J Ethnopharmacol. 2019
33. Sulindac imprinted mungbean starch/PVA biomaterial films as a transdermal drug delivery patch Carbohydr Polym. 2019
34. Marine Alga Ecklonia cava Extract and Dieckol Attenuate Prostaglandin E2 Production in HaCaT Keratinocytes Exposed to Airborne Particulate Matter Antioxidants (Basel). 2019
35. PKCι is a target of 7,8,4′-trihydroxyisoflavone for the suppression of UVB-induced MMP-1 expression Exp Dermatol. 2018
36. Effects on skin of Stichopus japonicus viscera extracts detected with saponin including Holothurin A: Down-regulation of melanin synthesis and upregulation of neocollagenesis mediated by ERK signaling pathway J Ethnopharmacol. 2018
37. The Ginsenoside Derivative 20(S)-Protopanaxadiol Inhibits Solar Ultraviolet Light-Induced Matrix Metalloproteinase-1 Expression J Cell Biochem. 2017
38. Acceleration of Apoptosis by Extracellular Basic pH in a 3D Human Skin Equivalent System Pharmacology. 2017
39. Acceleration of Collagen Breakdown by Extracellular Basic pH in Human Dermal Fibroblasts Skin Pharmacol Physiol. 2016
40. Brown Pine Leaf Extract and Its Active Component Trans-Communic Acid Inhibit UVB-Induced MMP-1 Expression by Targeting PI3K PLoS One. 2015
41. Flt3 is a target of cumestrol in protecting against UVB-induced skin photoaging. Biochemical Pharmacology Biochem Pharmacol. 2015
42. Topical delivery of retinol mulsions co-stabilised by PEO-PCLPEO triblock copolymers: effect of PCL block length J Microencapsul. 2012




논문 · Neoderm®-E

번호 논문자료 저널명 파일
1. Screening of Plant-Derived Natural Extracts to Identify a Candidate Extract Capable of Enhancing Lipid Synthesis in Keratinocytes Annals of Dermatology. 2022
2. Antimicrobial Effect of Supercritical Robinia pseudo-acacia Leaf Extracts and Its Transdermal Delivery System with Cell Penetrating Peptide International journal of advanced culture technology. 2020
3. Adiponectin enhances human keratinocyte lipid synthesis via SIRT1 and nuclear hormone receptor signaling J Invest Dermatol. 2019
4. Evaluation of the Antiviral Activity of a Green Tea Solution as a Hand-Wash Disinfectant Biosci Biotechnol Biochem. 2012
5. Interleukin-17 and Interleukin-22 Induced Proinflammatory Cytokine Production in Keratinocytes via Inhibitor of Nuclear FactorκB Kinase-α Expression Ann Dermatol. 2012
6. Filaggrin knockdown and Toll-like receptor 3 (TLR3) stimulation enhanced the production of thymic stromal lymphopoietin (TSLP) from epidermal layers Exp Dermatol. 2011




논문 · Neoderm®-ME

번호 논문자료 저널명 파일
1. Antimelanogenic potential of brewer's spent grain extract through modulation of the MAPK/MITF axis Sustainable Materials and Technologies. 2023
2. Neurog1-Derived Peptides RMNE1 and DualPep-Shine Penetrate the Skin and Inhibit Melanin Synthesis by Regulating MITF Transcription Journal of Functional Foods. 2023
3. Ultrasound-assisted pumpkin tendril extracts inhibits melanogenesis by suppressing the CREB/MITF signaling pathway in B16F10 melanoma cells, zebrafish, and a human skin model Journal of Functional Foods. 2023
4. Decursin prevents melanogenesis by suppressing MITF expression through the regulation of PKA/CREB, MAPKs, and PI3K/Akt/GSK-3β cascades Biomedicine & Pharmacotherapy. 2022
5. Maclurin Exhibits Antioxidant and Anti-Tyrosinase Activities, Suppressing Melanogenesis Antioxidant. 2022
6. Melanogenesis-promoting effect of Cirsium japonicum flower extract in vitro and ex vivo Int J Cosmet Sci. 2021
7. Di (Isoquinolin-1-Yl) Sulfane (DIQS) Inhibits Melaninogenesis by Modulating PKA/CREB and MAPK Signaling Pathways Cosmetics. 2021
8. Neobavaisoflavone Inhibits Melanogenesis through the Regulation of Akt/GSK-3β and MEK/ERK Pathways in B16F10 Cells and a Reconstructed Human 3D Skin Model Molecules. 2020
9. Exogenous pyruvate alleviates UV-induced hyperpigmentation via restraining dendrite outgrowth and Rac1 GTPase activity J dermaltological science. 2020
10. Anti-melanogenic effects of extracellular vesicles derived from plant leaves and stems in mouse melanoma cells and human healthy skin J extracellular vesicles. 2020
11. Spinosin is a flavonoid in the seed of Ziziphus jujuba that prevents skin pigmentation in a human skin model J Funct Foods. 2019
12. Amino acids disrupt calcium-dependent adhesion of stratum corneum PLoS One. 2019
13. Methyl-2-acetylamino-3-(4-hydroxyl-3,5-dimethoxybenzoylthio) propanoate suppresses melanogenesis through ERK signaling pathway mediated MITF proteasomal degradation J Dermatol Sci. 2018
14. Effect of 3,6‐anhydro‐l‐galactose on α‐melanocyte stimulating hormone‐induced melanogenesis in human melanocytes and a skin‐equivalent model J Cell Biochem. 2018
15. A novel anti-melanogenic agent, KDZ-001, inhibits tyrosinase enzymatic activity J Dermatol Sci. 2018
16. Anti-melanogenic activity of phytosphingosine via the modulation of the microphthalmia-associated transcription factor signaling pathway J Dermatol Sci. 2017
17. 2-(3, 4-dihydroxybenzylidene)malononitrile as a novel anti-melanogenic compound Oncotarget. 2017
18. Swertiajaponin inhibits skin pigmentation by dual mechanisms to suppress tyrosinase Oncotarget. 2017
19. Pectolinarigenin, an aglycone of pectolinarin, has more potent inhibitory activities on melanogenesis than pectolinarin Biochem Biophys Res Commun. 2017
20. Inhibitory effect of 2-methylnaphtho[1,2,3-de]quinolin-8-one on melanosome transport and skin pigmentation Sci Rep. 2016
21. Anti-Melanogenic Activity of Gagunin D, a Highly Oxygenated Diterpenoid from the Marine Sponge Phorbas sp., via Modulating Tyrosinase Expression and Degradation Mar Drugs. 2016
22. Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12 Arch Dermatol Res. 2015
23. Substance P Stimulates Endothelin 1 Secretion via Endothelin-Converting Enzyme 1 and Promotes Melanogenesis in Human Melanocytes J Invest Dermatol. 2015
24. Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model Int J Mol Sci. 2014
25. Novel inhibitory effect of the antidiabetic drug voglibose on melanogenesis Exp Dermatol. 2013




논문 · Neoderm®-M

번호 논문자료 저널명 파일
1. Anti-melanogenic effect of exosomes derived from human dermal fibroblasts (BJ-5ta-Ex) in C57BL/6 mice and B16F10 melanoma cells Pigment Cell & Melanoma Research. 2023
2. A Basic Domain-Derived Tripeptide Inhibits MITF Activity by Reducing its Binding to the Promoter of Target Genes J Invest Dermatol. 2021




논문 · Neoderm®-OD

번호 논문자료 저널명 파일
1. Effect of orodispersible hyaluronic acid film on palatal mucosa wound healing Oral Diseases. 2023
2. Intratympanic administration of alpha-lipoic acid-loaded pluronic F-127 nanoparticles ameliorates acute hearing loss Nanomedicine. 2020
3. Optimized phospholipid-based nanoparticles for inner ear drug delivery and therapy Biomaterials. 2018




논문 · Neoderm®-D

번호 논문자료 저널명 파일
1. Electric field‐induced changes in biomechanical properties in human dermal fibroblasts and a human skin equivalent Skin Res Technol. 2020
2. Effects of red ginseng on the elastic properties of human skin J Ginseng Res. 2019