Neoderm®-ED
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Composition

  • Epidermis
    • Human keratinocytes
  • Dermis
    • Human fibroblasts in collagen matrix

Characteristics

  • Neoderm®-ED consists of well-differentiated epidermal layers: cornified, granular, spinous and basal (Figure 1).
  • Proteins such as collagen IV, ki-67, and filaggrin are expressed in their specific locations (Figure 2 & 3).

Applications

  • Irritation test
    • Irritation test: Cell viability (MTT), IL-1α and PGE2 (ELISA)
  • Permeation test
    • Barrier function & Permeation test (HPLC)
  • Regeneration/elasticity test
    • Histological and morphological analyses (H&E stain)
    • MTT, ELISA, Western blot, PCR and IHC
    • Collagen synthesis
  • Wound healing test
    • H&E stain
  • Molecular biological analysis
    • Proteomics and RNA array

Well Type

6-well, 12-well

TEGO SCIENCE provides Contract Research Services using Neoderm®-ED